id: Pfam:PF12281
pfam_id: PF12281
name: Nucleotidyltransferase
short_name: NTP_transf_8
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12281
counters:
  proteins: 980
  matches: 982
  proteomes: 841
  taxa: 1524
  structures: 0
  alphafold_models: 635
  domain_architectures: 7
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR058575
description: 'This is a family of bacterial proteins that have a nucleotidyltransferase fold. The fold-prediction
  is backed up by conservation of three highly characteristic sequence motifs found in all other nucleotidyl
  transferases: i) pDhDhhh(h/p), where p is a polar residue and h is a hydrophobic residue; ii) upstream
  of the first, a GG/S; iii) a conserved D/E in a hydrophobic surround. In the classification of nucleotidyltransferases
  proposed in [[cite:PUB00066751]] this is a group XVIII NTP-transferase. Many of these sequences were
  classified in the COG database as COG5397. The exact function is not known.'