id: Pfam:PF12293
pfam_id: PF12293
name: Putative outer membrane core complex of type IVb secretion
short_name: T4BSS_DotH_IcmK
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12293
counters:
  proteins: 371
  matches: 378
  proteomes: 317
  taxa: 643
  structures: 14
  alphafold_models: 250
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022073
description: T4BSS_DotH_IcmK is a family of bacterial transporter proteins from Proteobacteria. DotH is
  an integral outer membrane component and it may form an outer membrane complex along with DotD and DotC
  functionally equivalent to secretins. DotH is the strongest candidate for the VirB9 counterpart of other
  T4BSS systems [[cite:PUB00075640]].