id: Pfam:PF12341
pfam_id: PF12341
name: Minichromosome loss protein, Mcl1, middle region
short_name: Mcl1_mid
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12341
counters:
  proteins: 3965
  matches: 4023
  proteomes: 3159
  taxa: 8329
  structures: 27
  alphafold_models: 3248
  domain_architectures: 104
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022100
description: Mcl1_mid, or the middle domain of minichromosome loss protein 1, is the domain that lies
  between a 7-bladed beta-propeller at the N-terminus, family WD40 [pfam:PF00400] etc, and a Homeobox
  (HMG) domain, [pfam:PF00505], at the C-terminus. The full length proteins with all three domains are
  referred to as DNA polymerase alpha accessory factor Mcl1, but the exact function of this domain is
  not known.