id: Pfam:PF12379
pfam_id: PF12379
name: Betacoronavirus replicase NSP3, N-terminal
short_name: bCoV_NSP3_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12379
counters:
  proteins: 308
  matches: 308
  proteomes: 3
  taxa: 63
  structures: 17
  alphafold_models: 7
  domain_architectures: 21
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR024358
description: This domain family corresponds to the N-terminal domain of NSP3 (non-structural protein 3,
  also known as nsp3) found in Betacoronavirus, which is encoded on the replicase polyprotein. This family
  includes the NSP3a domain which has the ubiquitin-like 1 (UB1) and glutamic acid-rich acidic (AC) hypervariable
  domains [[cite:PUB00094113]]. NSP3a interacts with numerous other proteins involved in replication and
  transcription and may serve as a scaffolding protein for these processes. The N-terminal NSP3a domain
  interacts with N (nucleocapsid) protein to colocalise genomic RNA with the nascent replicase-transcriptase
  complex at the earliest stages of infection, essential for the virus [[cite:PUB00094112]]. The C-terminal
  Glu-rich subdomain is best described as a flexible tail attached to the globular UB1 subdomain [[cite:PUB00047544]].
  The family is found in association with [pfam:PF08716], [pfam:PF01661], [pfam:PF05409], [pfam:PF06471],
  [pfam:PF08717], [pfam:PF06478], [pfam:PF09401], [pfam:PF06460], [pfam:PF08715], [pfam:PF08710].