id: Pfam:PF12401
pfam_id: PF12401
name: FhaA, N-terminal domain
short_name: FhaA_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12401
counters:
  proteins: 4333
  matches: 4335
  proteomes: 4028
  taxa: 5081
  structures: 1
  alphafold_models: 2532
  domain_architectures: 9
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022128
description: This domain can be found at the N terminus of FHA domain-containing protein Fha from Mycobacterium
  tuberculosis. The FHA (Fork Head Associated) domain is a phosphopeptide- specific binding domain that
  enables the protein to specifically bind to sequences containing phosphothreonine. FhaA is one of the
  major substrates of Ser/Thr protein kinases (STPK) [[cite:PUB00059641]] and plays a role in the regulation
  of cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan
  synthesis [[cite:PUB00057590]].