id: Pfam:PF12421
pfam_id: PF12421
name: Tip attachment protein J, C-terminal receptor binding domain
short_name: Ig_GpJ_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12421
counters:
  proteins: 91
  matches: 91
  proteomes: 58
  taxa: 172
  structures: 9
  alphafold_models: 54
  domain_architectures: 5
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021034
description: This entry represents the C-terminal receptor binding domain of Tip attachment protein J
  from Escherichia phage lambda (GpJ) and similar bacterial and viral proteins. J attaches the virion
  to the host receptor LamB, inducing viral DNA ejection. This domain, which determines the host specificity
  of the phage, shows an immunoglobulin-like fold [[cite:PUB00155963],[cite:PUB00109155]]. Many of the
  proteins in this entry are annotated as fibronectin type III. This domain was previously known as DUF3672
  and is normally found associated with [pfam:PF09327] and [pfam:PF13550].