id: Pfam:PF12432
pfam_id: PF12432
name: Integrator complex subunit 1, RP2B-binding domain
short_name: INTS1_RP2B-bd
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12432
counters:
  proteins: 1741
  matches: 1776
  proteomes: 1243
  taxa: 4101
  structures: 8
  alphafold_models: 141
  domain_architectures: 35
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022145
description: 'Integrator (INT) complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription
  and in their 3''-box-dependent processing. It binds the C-terminal domain (CTD) of RNA polymerase II
  (Pol II) and functions as an RNA endonuclease to cleave different classes of RNAs, regulating the transcription
  of both protein-coding genes and noncoding elements [[cite:PUB00152015],[cite:PUB00153137]]. Integrator
  also associates with protein phosphatase 2A (PP2A) core enzyme to form the INTAC complex [[cite:PUB00152015]]
  which regulates transcription through dephosphorylation of Pol II CTD. This entry includes the Integrator
  complex subunit 1 (INTS1) which forms the backbone module of the complex (it consists of four modules:
  backbone, shoulder, phosphatase and endonuclease) through the association with INTS2 and INTS7 to form
  a rigid scaffold. The backbone and shoulder modules form a central cruciform scaffold. INTS1 is an all-alpha
  helical protein with four repetitive helix hairpin domains towards the C-terminal (R1-R4) [[cite:PUB00152015]].
  This entry represents a domain found at the N-terminal of INTS1, which interacts with Pol II subunit
  RPB2 and form interface A [[cite:PUB00153137]].'