id: Pfam:PF12441
pfam_id: PF12441
name: CopG antitoxin of type II toxin-antitoxin system
short_name: CopG_antitoxin
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12441
counters:
  proteins: 916
  matches: 916
  proteomes: 740
  taxa: 1768
  structures: 0
  alphafold_models: 654
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022148
description: CopG antitoxin is a member of a type II toxin-antitoxin system family found in bacteria and
  archaea. Most antitoxins encoded by the relBE and parDE loci belong to the MetJ/Arc/CopG family of dimeric
  proteins which bind DNA through N-terminal ribbon-helix-helix (RHH) motifs [[cite:PUB00075548]]. The
  toxin for CopG proteins falls into the family BrnT_toxin, [pfam:PF04365].