id: Pfam:PF12480
pfam_id: PF12480
name: Golgi associated RAB2 interactor protein-like, Rab2B-binding domain
short_name: GARIL_Rab2_bd
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12480
counters:
  proteins: 2442
  matches: 2570
  proteomes: 325
  taxa: 1056
  structures: 0
  alphafold_models: 1670
  domain_architectures: 34
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022168
description: This domain is found in Golgi associated RAB2 interactor proteins and it is likely a Rab2B-binding
  domain [[cite:PUB00100833],[cite:PUB00100832],[cite:PUB00100834]]. Some members included in this entry,
  such as GAR1A/B and GAR2, are RAB2B effector proteins required for accurate acrosome formation and normal
  male fertility [[cite:PUB00100833],[cite:PUB00100834]]. GARI-L4 is a RAB2B effector protein required
  for the compacted Golgi morphology [[cite:PUB00100832]]. GARIL5 is a Rab2B effector protein which promotes
  cytosolic DNA-induced innate immune responses [[cite:PUB00100835]].