id: Pfam:PF12486
pfam_id: PF12486
name: Type VI secretion system, EvfB, or VasL
short_name: VasL
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12486
counters:
  proteins: 524
  matches: 524
  proteomes: 403
  taxa: 613
  structures: 0
  alphafold_models: 274
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021069
description: EvfB or VasL is a domain found on many Gram-negative proteins with an ImpA_N domain at the
  N-terminus. These proteins are expressed from the pathogenicity locus that forms the bacterial type
  VI secretion system. The exact function of VasL is not known. One E.coli member is annotated as being
  EvfB, though the E.coli equivalent of ImpA would be expected to be EvfG. It is possible that in many
  bacteria what is a single protein in one species, eg E.coli, is a fusion of two genes in others, which
  would explain an ImpA at the N-terminus and a VasL at the C-terminus.