id: Pfam:PF12530
pfam_id: PF12530
name: Focadhesin/RST1, DUF3730
short_name: DUF3730
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12530
counters:
  proteins: 2311
  matches: 2822
  proteomes: 1335
  taxa: 4349
  structures: 0
  alphafold_models: 506
  domain_architectures: 38
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022542
description: This domain of unknown function is found in Focadhesin from animals and RST1 (RESURRECTION
  1) from plants. Focadhesin (FOCAD) is a focal adhesion protein with potential tumour suppressor function
  in gliomas [[cite:PUB00075175]]. RST1 was originally identified in a genetic screen for factors involved
  in the biosynthesis of epicuticular waxes [[cite:PUB00098180]]. Later, RST1 and RST1 INTERACTING PROTEIN
  (RIPR) have been shown to act as cofactors of the cytoplasmic exosome and the Ski complex in plants
  [[cite:PUB00098179]]. It is involved in the suppression of siRNA-mediated silencing of transgenes and
  certain endogenous transcripts [[cite:PUB00098181]]. Structure predictions suggest that this is an alpha-helical
  domain with and armadillo-like fold.