id: Pfam:PF12534
pfam_id: PF12534
name: Pannexin-like TM region of LRRC8
short_name: Pannexin_like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12534
counters:
  proteins: 4357
  matches: 4478
  proteomes: 773
  taxa: 2372
  structures: 49
  alphafold_models: 3834
  domain_architectures: 114
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR021040
description: Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing
  8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect
  the cytosol to the extracellular space. The family is found in association with [pfam:PF00560] [[cite:PUB00075689]].