id: Pfam:PF12537
pfam_id: PF12537
name: The Golgi pH Regulator (GPHR) Family N-terminal
short_name: GPHR_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12537
counters:
  proteins: 3783
  matches: 3784
  proteomes: 2934
  taxa: 8060
  structures: 0
  alphafold_models: 3252
  domain_architectures: 51
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022535
description: GPHR_N is the N-terminal 5TM region of the Golgi pH regulator proteins in eukaryotes. It
  plays vital roles in the transport of newly synthesized proteins from the Golgi to the plasma membrane,
  in the glycosylation of proteins along the exocytic pathway and the structural organisation of the Golgi
  apparatus [[cite:PUB00059167],[cite:PUB00059166],[cite:PUB00109674]].