id: Pfam:PF12554
pfam_id: PF12554
name: Mitotic-spindle organizing gamma-tubulin ring associated
short_name: MOZART1
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12554
counters:
  proteins: 2874
  matches: 2874
  proteomes: 2400
  taxa: 6757
  structures: 36
  alphafold_models: 2443
  domain_architectures: 61
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022214
description: The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated
  with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC,
  one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and
  mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike
  the other four known subunits, this family does not carry the conserved 'Spc97-Spc98' GCP domain, so
  the TUBCGP nomenclature cannot be used for it. MOZART1 is required for gamma-TuRC recruitment to centrosomes
  [[cite:PUB00056001]].