id: Pfam:PF12597
pfam_id: PF12597
name: Cytochrome c oxidase assembly protein COX20
short_name: Cox20
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12597
counters:
  proteins: 2661
  matches: 2679
  proteomes: 2417
  taxa: 6450
  structures: 0
  alphafold_models: 2317
  domain_architectures: 29
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022533
description: Complex IV (CIV) is a copper-heme oxidase that couples electron transfer from cytochrome
  c to oxygen with proton extrusion across the inner membrane to contribute to the proton gradient required
  for ATP generation. This entry includes fungal mitochondrial complex IV assembly factor Cox20 [[cite:PUB00053731]]
  and its homologues (also known as FAM36A in metazoa [[cite:PUB00086694]]. Human CIV is formed by three
  catalytic core subunits (COX1/2/3). COX20 has been found to form a complex with SCO1, SCO2, and newly
  synthesized COX2. It may act as a chaperone in the early steps of COX2 maturation [[cite:PUB00088297]].