id: Pfam:PF12608
pfam_id: PF12608
name: Type IVb secretion, IcmS, effector-recruitment
short_name: T4bSS_IcmS
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12608
counters:
  proteins: 75
  matches: 75
  proteomes: 74
  taxa: 110
  structures: 4
  alphafold_models: 67
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR022250
description: This is a family of Gram-negative bacterial proteins involved in the Dot/Icm type IVb transport
  system. Members are small acidic cytoplasmic proteins required for Dot/Icm-dependent activities. Binary
  complexes of IcmW-IcmS and of IcmS-LvgA have been consistently reported, suggestive of the binary WXG100
  system. The IcmW-IcmS complex may play a role in recruitment of effector proteins to the transport apparatus
  [[cite:PUB00075640]].