id: Pfam:PF12707
pfam_id: PF12707
name: Protein of unknown function (DUF3804)
short_name: DUF3804
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12707
counters:
  proteins: 24
  matches: 25
  proteomes: 15
  taxa: 82
  structures: 1
  alphafold_models: 22
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR024525
description: This family is approximately 130 residues. Dali search indicates this protein carries a NTF2-fold
  with a hydrophobic cavity as a structural homologue to 1JB2, 2R4I, 3FSD and 2UX0. In this hydrophobic
  cavity, Arg 118 provides the H-bonding force to hold a PEG molecule from crystallisation. The interface
  interaction suggests that the biomolecule of [swissprot:Q46KI2] is a dimer. Two members of the family
  are annotated as putative EF-Tu domain 2 but there is no match to this family so this is likely to be
  a false assignment. There are two highly conserved tryptophan residues towards the C-terminal end of
  the family.