id: Pfam:PF12877
pfam_id: PF12877
name: UPF0606 protein KIAA1549 alpha/beta domain 2
short_name: KIAA1549
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12877
counters:
  proteins: 2272
  matches: 2276
  proteomes: 734
  taxa: 2277
  structures: 0
  alphafold_models: 670
  domain_architectures: 17
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR024606
description: This entry represents an alpha/beta domain found in the KIAA1549 protein from human ([swissprot:Q9HCM3])
  which has been implicated in pilocytic astrocytomas [[cite:PUB00056166],[cite:PUB00056167],[cite:PUB00056168]].
  It has been found to be fused to BRAF gene in many cases of pilocytic astrocytomas. The fusion is due
  mainly to a tandem duplication of 2 Mb at 7q34 [[cite:PUB00056166],[cite:PUB00056167]]. The BRAF protein
  is a well characterised oncoprotein. It is a serine/threonine protein kinase which is implicated in
  MAP/ERK signalling, a critical pathway for the regulation of cell division, differentiation and secretion
  [[cite:PUB00056166],[cite:PUB00056167],[cite:PUB00056168]]. More recently, KIAA1549 has been described
  to play a role in photoreceptor function [[cite:PUB00101492]]. This protein contains three homologous
  domains of this type found in tandem.