id: Pfam:PF12961
pfam_id: PF12961
name: Domain of unknown function (DUF3850)
short_name: DUF3850
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF12961
counters:
  proteins: 604
  matches: 604
  proteomes: 544
  taxa: 1185
  structures: 1
  alphafold_models: 282
  domain_architectures: 5
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR039440
description: The search results from NCBI sequence alignment indicates a conserved domain belonging to
  ASCH superfamily [[cite:PUB00044668]]. Dali searching results show that the protein is a structurally
  similar to the PUA domain, suggesting it may be involved in RNA recognition. It has been reported that
  the deletion of PUA genes results in impaired growth (RluD) and competitive disadvantage (TruB) in Escherichia
  coli. Suggestions have been put forward that, apart from their usual catalytic role, certain PUS enzymes
  (e.g. TruB) may also act as chaperones for RNA folding. The interface interaction indicates that the
  biomolecule of protein NP_809782.1 should be a dimer.