id: Pfam:PF13036
pfam_id: PF13036
name: Peptidoglycan-synthase activator LpoB
short_name: LpoB
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13036
counters:
  proteins: 2477
  matches: 2478
  proteomes: 2269
  taxa: 3652
  structures: 6
  alphafold_models: 1619
  domain_architectures: 14
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR014094
description: This is a family of Gram-negative bacterial outer membrane lipoproteins. LpoB is required
  for the function of the major peptidoglycan synthase enzyme PBP1B. It interacts with PBP1B protein via
  the UvrB-like non-catalytic domain on that protein. LpoB has a 54-aa-long flexible N-terminal stretch
  followed by a globular domain with similarity to the N-terminal domain of the prevalent periplasmic
  protein TolB. The long, flexible N-terminal region of LpoB enables it to span the periplasm and reach
  its docking site in PBP1B. Peptidoglycan is the essential polymer within the sacculus that surrounds
  the cytoplasmic membrane of bacteria [[cite:PUB00110446]].