id: Pfam:PF13072
pfam_id: PF13072
name: Mother cell inhibitor of FtsZ
short_name: MciZ
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13072
counters:
  proteins: 471
  matches: 471
  proteomes: 469
  taxa: 610
  structures: 2
  alphafold_models: 273
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025177
description: This family of proteins is found in bacteria. Family members are approximately 40 amino acids
  in length. There is a conserved GKAW sequence motif. There is a single completely conserved residue
  G that may be functionally important. Family members include the Bacillus subtilis cell-division inhibitor,
  MciZ (mother cell inhibitor of FtsZ) which blocks the assembly of FtsZ. FtsZ (filamentation temperature-sensitive
  Z) is the bacterial homolog of tubulin. Crystal structure reveals that MciZ binds to the C-terminal
  polymerization interface of FtsZ, the equivalent of the minus end of tubulin, causing shortening of
  protofilaments and blocking the assembly of higher-order FtsZ structures. Hence, MciZ provides a capping-based
  regulatory mechanism for FtsZ [[cite:PUB00091017]].