id: Pfam:PF13164
pfam_id: PF13164
name: Diedel
short_name: Diedel
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13164
counters:
  proteins: 173
  matches: 173
  proteomes: 82
  taxa: 367
  structures: 2
  alphafold_models: 159
  domain_architectures: 7
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025061
description: Diedel (die) was identified as an insect immune response protein. It is up-regulated after
  a septic injury and may act as a negative regulator of the JAK/STAT signalling pathway [[cite:PUB00078735]].
  Its homologues can be found in Drosophila and Acyrtosiphon pisum. Interestingly, the orthologues of
  the die gene are present in the genome of insect DNA viruses of the Baculoviridae and Ascoviridae families.
  The viral homologues suppress the immune deficiency (IMD) pathway in Drosophila [[cite:PUB00078736]].