id: Pfam:PF13165
pfam_id: PF13165
name: Six-cysteine peptide SCIFF
short_name: SCIFF
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13165
counters:
  proteins: 980
  matches: 983
  proteomes: 974
  taxa: 1678
  structures: 0
  alphafold_models: 672
  domain_architectures: 2
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR023975
description: Members of this protein family are essentially universal in the class Clostidia and therefore
  highly abundant in the human gut microbiome. This short peptide is designated SCIFF, for Six Cysteines
  in Forty-Five residues. It is a presumed ribosomal natural product precursor, always found associated
  with a yet-uncharacterised radical SAM protein that resembles other peptide modification radical SAM
  enzymes and is designated SCIFF radical SAM maturase [[cite:PUB00055953]].