id: Pfam:PF13244
pfam_id: PF13244
name: MBH, subunit D
short_name: MbhD
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13244
counters:
  proteins: 11122
  matches: 11122
  proteomes: 8758
  taxa: 12656
  structures: 5
  alphafold_models: 7166
  domain_architectures: 22
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025383
description: Hydrogen gas-evolving membrane-bound hydrogenase (MBH) is a respiratory complex homologous
  to the quinone-reducing Complex I. Like Complex I, MBH has peripheral and membrane arms. MBH is made
  of 14 subunits (MbhA-N). MbhJ, K, L, N and M form the Membrane-anchored hydrogenase module. MbhJ, K,
  L, N are predicted to be exposed to the cytoplasm and form the peripheral arm. The remaining 10 subunits
  are predicted to be integral membrane proteins forming the membrane arm, made of 44 transmembrane helices
  (TMH) [[cite:PUB00098955],[cite:PUB00098954]]. MbhA, B, C and F form the Sodium translocation module.
  MbhD, E, G and H form the Proton translocation module. MbhI is the linker between the hydrogenase module
  and the proton-translocating membrane module. It anchors the discontinuous TMH7 of MbhH via its middle
  lateral helix and the C-terminal of TMH2, found in MbhE. MbhD and MbhE together are equivalent to Nqo10
  of Complex I [[cite:PUB00098952]]. MbhD has three TM helices.