id: Pfam:PF13281
pfam_id: PF13281
name: MAP3K TRAFs-binding domain
short_name: MAP3K_TRAF_bd
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13281
counters:
  proteins: 4193
  matches: 4348
  proteomes: 1297
  taxa: 4235
  structures: 2
  alphafold_models: 1768
  domain_architectures: 83
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025136
description: This entry corresponds to the TNF receptor-associated factors (TRAFs)-binding domain found
  at the N-terminus of some MAP3Ks, like Apoptosis signal-regulating kinases (ASK). This domain is flanked
  by a thioredoxin-binding domain and a PH-like domain. It includes seven tetratricopeptide repeats (TPRs)
  and, together with the PH-like domain, constitutes the central regulatory domain of ASK1 [[cite:PUB00094650]].