id: Pfam:PF13297
pfam_id: PF13297
name: Replication stress response SDE2 C-terminal
short_name: SDE2_2C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13297
counters:
  proteins: 4063
  matches: 4067
  proteomes: 1782
  taxa: 5538
  structures: 50
  alphafold_models: 3532
  domain_architectures: 78
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025086
description: This domain represents the C-terminal region of the Replication stress response SDE2, a genome
  surveillance factor. It contains the DNA-binding SAP domain, frequently found in proteins involved in
  DNA repair. SDE2 C-terminal domain must be cleaved from its N-terminal at a diglycine motif within the
  ubiquitin-like fold, after Proliferating cell nuclear antigen (PCNA) interaction. This generates a functional
  protein that negatively regulates damage-inducible PCNA monoubiquitination, which then is proteolytically
  degraded to allow S phase progression and replication fork recovery in response to DNA damage [[cite:PUB00101934]].