id: Pfam:PF13338
pfam_id: PF13338
name: Transcriptional regulator, AbiEi antitoxin
short_name: AbiEi_4
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13338
counters:
  proteins: 4528
  matches: 4529
  proteomes: 2937
  taxa: 4980
  structures: 1
  alphafold_models: 2869
  domain_architectures: 30
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025159
description: AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial
  abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi
  system is activated upon infection with phage to abort the cell thus preventing the spread of phage
  through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded
  lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the
  plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread
  in bacteria and archaea. The cognate antitoxin is [pfam:PF13338] [[cite:PUB00075538]].