id: Pfam:PF13355
pfam_id: PF13355
name: ARC6-like, IMS domain
short_name: ARC6-like_IMS
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13355
counters:
  proteins: 1579
  matches: 1587
  proteomes: 668
  taxa: 1893
  structures: 7
  alphafold_models: 1214
  domain_architectures: 42
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025344
description: This domain corresponds to the C-terminal intermembrane space (IMS) region from protein accumulation
  and replication of chloroplasts 6 (ARC6) and its paralogue PARC6 [[cite:PUB00096838]]. ARC6 and PARC6
  are components of the plastid division machinery which are essential for the chloroplast replication
  process [[cite:PUB00096838],[cite:PUB00096839]], which implies the assembly and constriction of the
  tubulin-like FtsZ ring on the stromal surface of the inner envelope membrane (IEM) and the dynamin-like
  ARC5 ring on the cytosolic surface of the outer envelope membrane (OEM). ARC6 is evolutionarily related
  to the cyanobacterial cell division protein Ftn2/ZipN [[cite:PUB00096838]], having similar structures.
  This domain from ARC6 and PARC6 interacts with PDV2 and PDV1 respectively. PDV proteins recruit dynamin-like
  ARC5 ring to the chloroplast surface and mediates its constriction. ARC6/PARC6 are key to connect and
  coordinate Fst and ARC5 rings during fission [[cite:PUB00096837],[cite:PUB00096840]].