id: Pfam:PF13373
pfam_id: PF13373
name: DSC E3 ubiquitin ligase complex subunit 3, C-terminal domain
short_name: Dsc3_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13373
counters:
  proteins: 1525
  matches: 1558
  proteomes: 1454
  taxa: 3153
  structures: 0
  alphafold_models: 1291
  domain_architectures: 37
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025390
description: This is the C-terminal domain of DSC E3 ubiquitin ligase complex subunit 3 (Dsc3), which
  contains two transmembrane helices and a characteristic GFDRL sequence motif. Dsc3 is a component of
  the DSC E3 ubiquitin ligase complex (a Golgi-specific protein ubiquitination system) that functions
  in protein homeostasis under non-stress conditions, playing a role in protein quality control [[cite:PUB00098312],[cite:PUB00098082],[cite:PUB00098314]].
  Yeast DSC E3 ubiquitin ligase complex is the homologue of Hrd1 E3 ligase complex from mammals, in which
  Dsc1, Dsc2 and Dsc3 corresponds to Hrd1, Der1, and Usa1, respectively. Dsc3 is a Herp-like protein that
  acts as a bridge between Dsc1 and Dsc2 for their interaction [[cite:PUB00075404]].