id: Pfam:PF13689
pfam_id: PF13689
name: YfiR/HmsC-like
short_name: DUF4154
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13689
counters:
  proteins: 2780
  matches: 2788
  proteomes: 1988
  taxa: 3030
  structures: 12
  alphafold_models: 1729
  domain_architectures: 17
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025293
description: This family of proteins is found in bacteria and includes YfiR from E. coli. YfiR has been
  shown to regulate YfiN, a diguanylate cyclase and a bifunctional protein that produces c-di-GMP in response
  to reductive stress and then dynamically relocates to the division site to arrest cell division in response
  to envelope stress in Escherichia coli. YfiR may serve as a periplasmic redox sensor that regulates
  YfiN activity in response to reducing conditions [[cite:PUB00088310],[cite:PUB00088309]]. HmsC in Yersinia
  Pestis is the orthologue of YfiR from E. coli [[cite:PUB00091013]]. HmsC is a periplasmic protein that
  interacts directly with the periplasmic domain (PD) of HmsD and causes proteolytic degradation of HmsD,
  which in turn negatively regulates Y. pestis biofilm formation [[cite:PUB00091014]].