id: Pfam:PF13910
pfam_id: PF13910
name: EMARD, N-terminal domain
short_name: EMARD_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF13910
counters:
  proteins: 1409
  matches: 1523
  proteomes: 793
  taxa: 2656
  structures: 0
  alphafold_models: 1213
  domain_architectures: 24
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025209
description: This entry represents the KEN domain found at the N-terminal of Endoplasmic reticulum membrane-associated
  RNA degradation protein (EMARD, also known as C6orf70 in human), which belongs to the HEPN superfamily.
  It carries the characteristic, highly conserved RxxxxHG sequence motif [[cite:PUB00091124]]. This domain
  may be a RNase that is involved in the degradation of rRNAs, mRNAs associated with the endoplasmic reticulum
  membrane. EMARD may play a role in neuronal migration during embryonic development [[cite:PUB00089893]].