id: Pfam:PF14023
pfam_id: PF14023
name: Bestrophin-like domain
short_name: Bestrophin-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14023
counters:
  proteins: 4843
  matches: 4851
  proteomes: 3237
  taxa: 4565
  structures: 0
  alphafold_models: 2878
  domain_architectures: 17
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025333
description: This family of domains is functionally uncharacterised, however it is distantly related to
  bestrophin proteins. Structure prediction suggests that these proteins can form homopentamers as Bestrophin
  proteins do. These proteins may function as chloride channels. This domain is sometimes found at the
  C-terminus in large RHS proteins suggesting that it may function as a toxin. This domain was formerly
  known as DUF4239.