id: Pfam:PF14026
pfam_id: PF14026
name: Nickel responsive protein SCO4226-like
short_name: SCO4226-like
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14026
counters:
  proteins: 3059
  matches: 3085
  proteomes: 2553
  taxa: 3944
  structures: 2
  alphafold_models: 1873
  domain_architectures: 13
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025336
description: This family of proteins is found in prokaryotes, including the nickel responsive protein
  SCO4226 from Streptomyces coelicolor ([swissprot:Q9FCE4]). SCO4226 adopts a dimeric configuration able
  to bind four nickel ions, with each monomer showing a typical ferredoxin-like fold with five beta-strands
  packing against two alpha-helices. It seems to play a role in cellular nickel homeostasis, detoxification,
  and/or nickel utilization in specialised cytoplasmic compartment [[cite:PUB00093075]].