id: Pfam:PF14112
pfam_id: PF14112
name: Immunity protein 22
short_name: DUF4284
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14112
counters:
  proteins: 558
  matches: 564
  proteomes: 502
  taxa: 869
  structures: 0
  alphafold_models: 333
  domain_architectures: 5
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025560
description: A predicted immunity protein with an alpha+beta fold and conserved tryptophan,tyrosine and
  an acidic residues. Proteins containing this domain are present in bacterial polymorphic toxin systems
  as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the ColD/E5,
  Tox-REase-4, Ntox49 or Ntox14 families [[cite:PUB00066726]]. The domain is also found in heterogeneous
  polyimmunity loci.