id: Pfam:PF14113
pfam_id: PF14113
name: Type VI secretion system (T6SS), amidase effector protein 4
short_name: Tae4
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14113
counters:
  proteins: 965
  matches: 969
  proteomes: 728
  taxa: 1386
  structures: 10
  alphafold_models: 549
  domain_architectures: 23
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025562
description: Tae4 is a new form of toxin-antitoxin system protein for a type VI secretion system, T6SS.
  T6SS has roles in interspecies interactions, as well as higher order host-infection, by injecting effector
  proteins into the periplasmic compartment of the recipient cells of closely related species. Pseudomonas
  aeruginosa produces at least three effector proteins to other cells and thus has three specific cognate
  immunity proteins to protect itself. Tae4, or type VI amidase effector 4, in Enterobacter cloacae has
  a cognate Tai4 or type VI amidase immunity 4 protein [[cite:PUB00075621]]. The immunity protein is Tai4,
  [pfam:PF16695].