id: Pfam:PF14159
pfam_id: PF14159
name: CAAD domains of cyanobacterial aminoacyl-tRNA synthetase
short_name: CAAD
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14159
counters:
  proteins: 3537
  matches: 3553
  proteomes: 674
  taxa: 1866
  structures: 0
  alphafold_models: 2760
  domain_architectures: 68
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025564
description: This domain is present in aminoacyl-tRNA synthetases (aaRSs), enzymes that couple tRNAs to
  their cognate amino acids [[cite:PUB00066703]]. aaRSs from cyanobacteria containing the CAAD (for cyanobacterial
  aminoacyl-tRNA synthetases appended domain) protein domains are localised in the thylakoid membrane.
  The domain bears two putative transmembrane helices and is present in glutamyl-, isoleucyl-, leucyl-,
  and valyl-tRNA synthetases, the latter of which has probably recruited the domain more than once during
  evolution.