id: Pfam:PF14243
pfam_id: PF14243
name: ATP-grasp domain, R2K clade family 3
short_name: R2K_3
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14243
counters:
  proteins: 1184
  matches: 1190
  proteomes: 1071
  taxa: 1851
  structures: 0
  alphafold_models: 664
  domain_architectures: 6
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025643
description: Family of ATP-grasp enzymes belonging to the R2K clade, wherein one of the absolutely-conserved
  lysine residues has migrated to the RAGYNA domain which is a part of the core ATP-grasp module. This
  family is predicted to catalyze peptide ligation reactions on protein substrates in biological conflict
  contexts, probably between bacteriophages and their hosts [[cite:PUB00091030]].