id: Pfam:PF14251
pfam_id: PF14251
name: PterinBD-DUF4346
short_name: PterinBD-DUF4346
seed_status: KNOWN_HISTORICAL_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14251
counters:
  proteins: 775
  matches: 781
  proteomes: 668
  taxa: 1712
  structures: 0
  alphafold_models: 574
  domain_architectures: 16
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025595
description: 'This domain is found in bacteria, archaea and a few lower eukaryotes species. There are
  two conserved sequence motifs: LDP and DHA. Many members of this family have been annotated as dihydropteroate
  synthases, however no experimental evidence can be found for this and [swissprot:Q57571] has been shown
  not to possess dihydropteroate synthase activity [[cite:PUB00057368]]. In bacteria, this domain is found
  in predicted conflict systems that also encode genes for an active Thymidylate synthase and a pterin-dependent
  one-carbon carrier (MtrA domain). This system is predicted to deplete virally generated nucleotides
  and replace them with a nucleotide that restricts invasive DNA or protects host DNA [[cite:PUB00155486]].'