id: Pfam:PF14254
pfam_id: PF14254
name: Domain of unknown function (DUF4348)
short_name: DUF4348
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14254
counters:
  proteins: 214
  matches: 214
  proteomes: 212
  taxa: 344
  structures: 2
  alphafold_models: 135
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025590
description: Two structures have been solved form this DUF, PDB:4mjf and PDB:3sbu. TOPSAN records that
  both proteins are the only structural representatives of Pfam PF14254, DUF4348. There are no other significant
  hits in FFAS. DUF4348 has ~200 proteins, all from Bacteroidetes, and all with a single domain architecture
  with just one DUF4348 domain. There appears to be a possible gene duplication in the protein as the
  N-terminal domain (approx residues 25-174) and C-terminal domain (approx residues 175-286) superimpose
  quite well with ~1.9A r.m.s.d. and ~30% sequence identity.