id: Pfam:PF14263
pfam_id: PF14263
name: Domain of unknown function (DUF4354)
short_name: DUF4354
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14263
counters:
  proteins: 74
  matches: 74
  proteomes: 70
  taxa: 154
  structures: 2
  alphafold_models: 41
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025581
description: Several members of this family are annotated as being ATP/GTP-binding site motif A (P-loop)
  proteins, but this could not be confirmed. The one PDB:3NRF structure solved for this family exhibits
  an immunoglobin-like beta-sandwich fold. Crystal packing suggests that a tetramer is a significant oligomerisation
  state, and a disulfide bridge is formed between Cys 125 at the C-terminal end of the monomer, and Cys
  69.