id: Pfam:PF14325
pfam_id: PF14325
name: Domain of unknown function (DUF4383)
short_name: DUF4383
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14325
counters:
  proteins: 3778
  matches: 3778
  proteomes: 2396
  taxa: 3221
  structures: 0
  alphafold_models: 2153
  domain_architectures: 5
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
description: This family of proteins is functionally uncharacterised. This family of proteins is found
  in bacteria. Proteins in this family are typically between 137 and 164 amino acids in length. These
  proteins are integral membrane proteins with four transmembrane helices. The contain several conserved
  histidines and AlphaFold 3 predicts a confident zinc binding site. Structure prediction also suggests
  that these proteins might form a homotetrameric complex UniProt:A0A3B9LPY9 iPTM=0.9. The four subunits
  are alternating in different orientations in the presumed membrane. The structure prediction also suggests
  a central pore between the subunits.