id: Pfam:PF14336
pfam_id: PF14336
name: D-glutamate cyclase-like, C-terminal
short_name: GLUCM-like_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14336
counters:
  proteins: 1872
  matches: 1931
  proteomes: 1349
  taxa: 3617
  structures: 6
  alphafold_models: 1483
  domain_architectures: 16
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025504
description: This entry represents the C-terminal domain of mitochondrial D-glutamate cyclase, which converts
  D-glutamate to 5-oxo-D-proline [[cite:PUB00086027]]. This is a conserved domain also found in uncharacterised
  proteins from bacteria and archaea. Structural studies of the hypothetical protein TON_0340 from Thermococcus
  onnurineus revealed an active-site cavity harbouring a metal-binding site containing six invariant aspartate
  and glutamate residues that adopts an alpha/beta-structure [[cite:PUB00151593]]. Biochemical and mutational
  analysis show that TON_0340 is a Mn+2-dependent phosphatase [[cite:PUB00151593]].