id: Pfam:PF14365
pfam_id: PF14365
name: Neprosin activation peptide
short_name: Neprosin_AP
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14365
counters:
  proteins: 8262
  matches: 8485
  proteomes: 378
  taxa: 1061
  structures: 3
  alphafold_models: 6531
  domain_architectures: 163
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025521
description: Pitcher plants are insectivorous and secrete a digestive fluid into the pitcher. This fluid
  contains a mixture of enzymes including peptidases. One of these is neprosin, characterized from the
  pitcher plant Nepenthes ventrata. This peptidase is of unknown catalytic type and is unaffected by standard
  peptidase inhibitors. Unusually, activity is directed towards prolyl bonds, but unlike most peptidase
  that cleave after proline, there is no restriction on sequence length or position of the proline residue.
  The peptidase is secreted and is presumed to possess an N-terminal activation peptide [[cite:PUB00081922]].
  This domain corresponds to the presumed activation peptide.