id: Pfam:PF14377
pfam_id: PF14377
name: Ubiquitin binding region
short_name: UBM
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14377
counters:
  proteins: 8833
  matches: 22640
  proteomes: 3156
  taxa: 8298
  structures: 23
  alphafold_models: 2922
  domain_architectures: 363
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025527
description: This family contains repetitive element (RE) from a subgroup of HECT E3 ubiquitin ligases
  and the Y-family translesion polymerases, including human HUWE1 and Arabidopsis UPL1. Each of these
  repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments
  separated by a Leu-Pro motif. The REs from the Y-family polymerases were shown to bind ubiquitin and
  were the basis for a novel ubiquitin-binding domain called the ubiquitin-binding motif (UBM) [[cite:PUB00091009]].