id: Pfam:PF14384
pfam_id: PF14384
name: BrnA antitoxin of type II toxin-antitoxin system
short_name: BrnA_antitoxin
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14384
counters:
  proteins: 4185
  matches: 4187
  proteomes: 2551
  taxa: 4274
  structures: 0
  alphafold_models: 2792
  domain_architectures: 4
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025528
description: BrnA is family of antitoxins that neutralises the toxin BrnT, [pfam:PF04365]. It consists
  of 3 alpha-helices and a C-terminal ribbon-helix-helix DNA binding domain. As in other toxin-antitoxin
  systems, BrnA negatively autoregulates the brnTA operon and has higher affinity for the DNA operator
  when complexed with BrnT. It dimerises with two molecules of its toxin BrnT [[cite:PUB00058380]].