id: Pfam:PF14466
pfam_id: PF14466
name: PLAT/LH2 and C2-like Ca2+-binding lipoprotein
short_name: PLCC
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14466
counters:
  proteins: 58
  matches: 58
  proteomes: 52
  taxa: 112
  structures: 2
  alphafold_models: 39
  domain_architectures: 1
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025219
description: A small family of bacterial proteins, found in several Bacteroides species. Structure determination
  (NMR and Xray) shows an immunoglobulin beta-barrel fold. Multiple homologues have been found in human
  gut metagenomics data sets. Structural experimentation shows it to share features with two well-established
  protein architectures in the SCOP database, ie, C2 (calcium/lipid-binding domain) of [pfam:PF00168]
  and PLAT/LH2 (lipase/lipooxigenase domain) of [pfam:PF01477]. The C2 and PLAT/LH2 domains bind Ca2+
  in their functions of targeting proteins to cell-membranes; this domain is also shown to bind Ca2+ as
  well as to be a novel fold [[cite:PUB00075637]].