id: Pfam:PF14467
pfam_id: PF14467
name: Domain of unknown function (DUF4426)
short_name: DUF4426
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14467
counters:
  proteins: 1617
  matches: 1617
  proteomes: 1606
  taxa: 2118
  structures: 1
  alphafold_models: 981
  domain_architectures: 3
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR025218
description: Members of this entry are found mostly in g-proteobacteria, especially in Vibrio. Strangely
  enough, there seems to be one eukaryotic homolog in Nematostella vectensis (NEMVEDRAFT_v1g226006), where
  the PA0388-like domain is fused with a domain homogous to the Methionine biosynthesis protein MetW (see
  below). In several Pseudomonas species, but also in Vibrio vulnificus and Azotobacter vinelandii PA0388
  homologs are genomic neighbors of Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific) (EC
  3.6.1.15) and Methionine biosynthesis protein MetW. On the other hand, in most Vibrio species it appears
  as a part of a conserved operon involved in possible response to stress.