id: Pfam:PF14534
pfam_id: PF14534
name: Domain of unknown function (DUF4440)
short_name: DUF4440
seed_status: UNKNOWN_CANDIDATE
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14534
counters:
  proteins: 20901
  matches: 21018
  proteomes: 9416
  taxa: 13277
  structures: 14
  alphafold_models: 13058
  domain_architectures: 127
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR027843
description: This domain is found in uncharacterised proteins from bacteria, archaea and eukaryotes, including
  NTF2-Like SgcJ protein from Streptomyces carzinostaticus, which plays a role in the biosynthesis of
  the 9-membered enediyne antitumor antibiotic C-1027. It shows a cone-like alpha+beta barrel structure
  with a long N-terminal alpha- helix, a curved six-stranded antiparallel beta-sheet and two additional
  shorter alpha-helices. Its specific function is still unkown [[cite:PUB00100883]].