id: Pfam:PF14613
pfam_id: PF14613
name: HAM1-like, C-terminal domain
short_name: HAM1_C
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14613
counters:
  proteins: 1927
  matches: 1931
  proteomes: 1257
  taxa: 2678
  structures: 0
  alphafold_models: 1593
  domain_architectures: 29
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR027842
description: This is a domain found at the C-terminal end of the putative cell signalling protein HAM1
  from Cryptococcus neoformans and similar fungal sequences. HAM1 may act as a negative regulator of mating
  during vegetative growth [[cite:PUB00110896]]. Proteins with this domain often also contain an N-terminal
  domain [pfam:PF19343]. The member [swissprot:Q7SB48], named HAM-13, is thought to associate with MAPKs
  and to be required for proper cell communication but it is also possible to be involved in other processes
  such as cell signalling or trafficking [[cite:PUB00110895]].