id: Pfam:PF14780
pfam_id: PF14780
name: Nucleolus and neural progenitor protein, N-terminal
short_name: NEPRO_N
seed_status: EX_DUF
characterization_status: UNSCORED
curation_status: SEEDED
source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/PF14780
counters:
  proteins: 2220
  matches: 2231
  proteomes: 1669
  taxa: 5231
  structures: 3
  alphafold_models: 1930
  domain_architectures: 29
provenance:
  snapshot_id: interpro-pfam-duf-2026-10-10
  path: data/worklists/interpro-pfam-duf-2026-10-10.json
  sha256: 17fb625876c9326ed284263a47bcd84e0d7844a31c040dc06cd2260c36f1c383
  generated_at: '2026-10-10T07:44:21.614711Z'
  source_url: https://www.ebi.ac.uk/interpro/api/entry/pfam/
interpro_id: InterPro:IPR027951
description: This domain is found at the N-terminal of nucleolus and neural progenitor protein (NEPRO)
  which may play a role in cortex development as part of the Notch signalling pathway. Downstream of Notch
  may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining
  neural progenitors [[cite:PUB00101272]]. NEPRO may also play a role in preimplentation embryo development
  [[cite:PUB00101273]]. NEPRO interacts with multiple protein subunits of RMRP and is implicated in Anauxetic
  dysplasia 3 [[cite:PUB00101274]]. NEPRO is likely the human orthologue of RMP1 subunit from yeast and
  they share a four-helix bundle domain structure.